An epistatic explanation

eLife

Yuji Mishina¹  Yoshihiro Komatsu² 

[1] Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, United States;Department of Pediatrics, The University of Texas Medical School at Houston, Houston, United States;

关键词: craniosynostosis;    craniofacial;    exome sequencing;    human genetics;    de novo mutation;    incomplete penetrance;   

DOI  :  10.7554/eLife.21162

来源: DOAJ

【 摘 要 】

Interactions between two gene variants that rarely cause midline craniosynostosis on their own make the development of the disorder a certainty.

【 授权许可】

Unknown