Utility of Contrast-Enhanced Harmonic Endoscopic Ultrasonography for Early Diagnosis of Small Pancreatic Cancer

Diagnostics

Kensuke Tanioka¹  Tetsuo Sonomura²  Masaki Terada³  Yasunobu Yamashita⁴  Masahiro Itonaga⁴  Takeichi Yoshida⁴  Junya Nuta⁴  Keiichi Hatamaru⁴  Takashi Tamura⁴  Yoshiyuki Ida⁴  Takao Maekita⁴  Mikitaka Iguchi⁴  Masayuki Kitano⁴  Yuki Kawaji⁴  Hiroki Yamaue⁵  Manabu Kawai⁵  Seiko Hirono⁵  Ken-Ichi Okada⁵ 

[1] Clinical Study Support Center, Wakayama Medical University Hospital, Wakayama 641-8509, Japan;Department of Radiology, Wakayama Medical University, Wakayama 641-8509, Japan;Department of Radiology, Wakayama Minami Radiology Clinic, Wakayama 641-0012, Japan;Second Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan;Second Department of Surgery, Wakayama Medical University, Wakayama 641-8509, Japan;

关键词: early diagnosis of pancreatic cancer;    contrast-enhanced harmonic endoscopic ultrasonography;    magnetic resonance imaging;    multidetector computed tomography;   

DOI  :  10.3390/diagnostics10010023

来源: DOAJ

【 摘 要 】

This study aimed to assess whether contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS), compared to multidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI), is useful for early diagnosis of small pancreatic cancer (PC). Between March 2010 and June 2018, all three imaging modalities and surgery were performed for patients with a pancreatic solid lesion measuring ≤20 mm; diagnostic ability was compared among modalities. Fifty-one of 60 patients were diagnosed with PC (PC size in 41 patients: 11−20 mm; 10 patients: ≤10 mm). The sensitivity, specificity, and accuracy of CH-EUS, MDCT, and MRI for PC (11−20 mm) detection were 95%/83%/94%, 78%/83%/79%, and 73%/33%/68%, respectively. The diagnostic ability of CH-EUS was significantly superior compared with MDCT and MRI (p = 0.002 and p = 0.007, respectively). The sensitivity, specificity, and accuracy of CH-EUS, MDCT, and MRI for PC (≤10 mm) detection were 70%/100%/77%, 20%/100%/38%, and 50%/100%/62%, respectively. The diagnostic ability of CH-EUS tended to be superior to that of MDCT (p = 0.025). The sensitivity of MDCT for PC (≤10 mm) detection was significantly lower than that for PC (11−20 mm) detection (20% vs. 78%; p = 0.001). CH-EUS, compared to MDCT and MRI, is useful for diagnosing small PCs.

【 授权许可】

Unknown