Antibacterial Chitosan Nanofiber Thin Films with Bacitracin Zinc Salt

Polymers

Meng-Jiy Wang¹  Yuki Shirosaki²  Kazutaka Kumamoto²  Satoshi Hayakawa³  NurulAsyifah Binti Mustapha⁴  Toshinari Maeda⁴ 

[1] Department of Chemical Engineering, National Taiwan University of Science and Technology, No. 43, Sec. 4, Keelung Rd., Taipei 106, Taiwan;Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-Cho, Tobata-Ku, Kitakyushu, Fukuoka 804-8550, Japan;Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan;Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0196, Japan;

关键词: chitosan nanofiber;    thin film;    antibacterial properties;    fibroblast viability;   

DOI  :  10.3390/polym13071104

来源: DOAJ

【 摘 要 】

Chitosan nanofiber has a highly uniform structure of 20–50 nm in diameter and shows high dispersibility in water due to its submicron size and high surface-to-volume ratio. The stacked nanofibers film is useful for breathability because it has a gap with a size of several tens of nm or more. However, the chemical bonds between the nanofibers cannot be broken during use. In this study, the thin films were obtained by filtration of chitosan nanofibers and 3-glycidoxypropyltrimethoxysilane (GPTMS) mixture. The addition of GPTMS changed the wettability, mechanical property and stability in water of the thin films. Bacitracin zinc salt (BZ) has been used for the localized dermatological medicines and loaded in the films. BZ interacted electrostatically with the thin films matrix and the release of BZ was controlled by the amount of GPTMS. A higher released amount of BZ showed higher antibacterial effects toward S. aureus. The film was also tested their toxicity by L929 fibroblasts. The release of less than 11.9 μg of BZ showed antibacterial effects, but were not toxic for fibroblast cells.

【 授权许可】

Unknown