Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials

Journal of Functional Biomaterials

Kazuo Azuma³  Ryotaro Izumi¹  Tomohiro Osaki³  Shinsuke Ifuku¹  Minoru Morimoto²  Hiroyuki Saimoto¹  Saburo Minami³  Yoshiharu Okamoto³ 

[1] Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan; E-Mails:;Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, 4-101 Koyama-minami, Tottori 680-8550, Japan; E-Mail:;Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan; E-Mails:

关键词: chitin;    chitosan;    wound healing;    chitin nanofiber;    chitosan nanofiber;    animal experiments;    adhesive;   

DOI  :  10.3390/jfb6010104

来源: mdpi

【 摘 要 】

Chitin (β-(1-4)-poly-N-acetyl-d-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.