Intestinal shedding of enteric agents in histo-blood group antigen-secretor children in an Australian community-based birth cohort study

Journal of Pediatric and Neonatal Individualized Medicine

Stephen B. Lambert¹  David M. Whiley²  Keith Grimwood³  Peter D. Sly³  Robert S. Ware⁴  Gabor Mihala⁴  Catherine Cheung⁵ 

[1] Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia;National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia;Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia;Menzies Health Institute Queensland and School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia;Queensland Paediatric Infectious Diseases Laboratory, Children’s Health Queensland, South Brisbane, Queensland, Australia;

关键词: infection;    host susceptibility;    histo-blood group antigens;    secretor phenotype;    norovirus;    blastocystis;   

DOI  :  10.7363/110116

来源: DOAJ

【 摘 要 】

Histo-blood group antigens are inherited polymorphic glycans expressed on mucosal epithelial cell surfaces and shed in secretions. They act as receptors for gastrointestinal pathogens. Those expressing these antigens are categorized as secretors and have an increased susceptibility to gastrointestinal infections, particularly from some norovirus and rotavirus genotypes. However, high-level evidence of association between secretor status and susceptibility is lacking for many other gastrointestinal pathogens. We compared differences in detection rates for 8 viruses, 5 bacteria, and 4 protozoa in children under 2 years of age enrolled in the Australian Observational Research in Childhood Infectious Diseases birth cohort study. Their secretor status was determined by phenotyping (ABO, Lewis, UEA-I) and genotyping test results. Data from polymerase chain reaction assay testing of weekly stool samples collected from birth as well as daily symptom and illness diaries were analyzed. Incidence rates were calculated by secretor status and compared using incidence rate ratios for each pathogen. Additional comparisons included symptomatic/asymptomatic detections, illness severity, and healthcare utilization by secretor status. Eighty-four children (77% secretors) participated for an exposure period of 157 child-years. The incidence rates of norovirus GI, GII, wild-type rotavirus, and Campylobacter detections were more than 50% higher in secretors than non-secretors, but lower for Blastocystis. For these pathogens, secretor status was not associated with symptomatic illness, severity, or healthcare use. Our results confirmed the previously known higher susceptibility to norovirus GII infections in secretors but displayed variations in susceptibility to other pathogens. This study strengthens the evidence for norovirus susceptibility in Australian children.

【 授权许可】

Unknown