Norovirus Attachment and Entry

Viruses

CraigB. Wilen¹  Jin Wei¹  VincentR. Graziano¹ 

[1] Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA;

关键词: norovirus entry;    CD300lf;    JAM-A;    bile salts;    histo-blood group antigens;    murine norovirus;    viral tropism;   

DOI  :  10.3390/v11060495

来源: DOAJ

【 摘 要 】

Human norovirus is a major human pathogen causing the majority of cases of viral gastroenteritis globally. Viral entry is the first step of the viral life cycle and is a significant determinant of cell tropism, host range, immune interactions, and pathogenesis. Bile salts and histo-blood group antigens are key mediators of norovirus entry; however, the molecular mechanisms by which these molecules promote infection and the identity of a potential human norovirus receptor remain unknown. Recently, there have been several important advances in norovirus entry biology including the identification of CD300lf as the receptor for murine norovirus and of the role of the minor capsid protein VP2 in viral genome release. Here, we will review the current understanding about norovirus attachment and entry and highlight important future directions.

【 授权许可】

Unknown