Mechanisms of ATP Release by Inflammatory Cells

International Journal of Molecular Sciences

Michel Dosch¹  Guido Beldi¹  Joël Gerber¹  Fadi Jebbawi¹ 

[1] Department for Visceral Surgery and Medicine, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland;

关键词: ATP release;    extracellular nucleotides;    purinergic signaling;    inflammation;    monocytes/macrophages;    neutrophils;    endothelial cells;    non-specific nucleotide release;    vesicular exocytosis;    connexins;    pannexins;   

DOI  :  10.3390/ijms19041222

来源: DOAJ

【 摘 要 】

Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during inflammation. Necrosis leads to non-specific release of nucleotides, whereas specific release mechanisms include vesicular exocytosis and channel-mediated release via connexin or pannexin hemichannels. These release mechanisms allow stimulated inflammatory cells such as macrophages, neutrophils, and endothelial cells to fine-tune autocrine/paracrine responses during acute and chronic inflammation. Key effector functions of inflammatory cells are therefore regulated by purinergic signaling in acute and chronic diseases, making extracellular nucleotide release a promising target for the development of new therapies.

【 授权许可】

Unknown