Activation of human eosinophils via P2 receptors: novel findings and future perspectives

Journal of Leukocyte Biology

Andrea la Sala⁴  Marco Idzko³  Johannes Norgauer¹  Davide Ferrari²  Elisabeth Panther⁵  Francesco Di Virgilio² 

[1] Department of Dermatology, University of Jena, Germany; and Department of Dermatology, University of Jena, Germany; and Department of Dermatology, University of Jena, Germany; andDepartment of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Italy; Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Italy; Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Italy;;Department of Pneumology, University of Freiburg, Germany Department of Pneumology, University of Freiburg, Germany Department of Pneumology, University of Freiburg, GermanyLaboratory of Molecular and Cellular Biology, IRCCS, San Raffaele, Rome, Italy; Laboratory of Molecular and Cellular Biology, IRCCS, San Raffaele, Rome, Italy; Laboratory of Molecular and Cellular Biology, IRCCS, San Raffaele, Rome, Italy;Department of Gastroenterology, University of Freiburg, Germany; Department of Gastroenterology, University of Freiburg, Germany; Department of Gastroenterology, University of Freiburg, Germany;

关键词: extracellular nucleotides;    inflammation;   

DOI  :  10.1189/jlb.0505286

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

A growing body of information indicates that release of intracellular nucleotides represents an important way to modulate several cell pathways in physiological or pathological conditions. Nucleotides released as a consequence of cell damage, cell stress, bacterial infection, or other noxious stimuli signal at a class of plasma membrane receptorsP2 receptorsactivating diverse intracellular pathways in many tissues and organs. For example, nucleotides secreted in the airway system control chloride/liquid secretion, goblet cell degranulation, and ciliary beat frequency. Several studies indicate that nucleotides play a role in airway diseases through their action on multiple cell types, including mast cells, dendritic cells, neurons, and eosinophils. Recent work by us and other groups led to the identification and characterization of P2 receptors expressed by human eosinophils. In this review, we will summarize recent developments in this field and put forward a hypothesis about the role of P2 receptors in pathophysiological conditions where eosinophils are major players.

【 授权许可】

Unknown