Association analysis ofACE ,ACTN3andPPARGC1Agene polymorphisms in two cohorts of European strength and power athletes

Biology of Sport

关键词: Actinin;    Angiotensinogen;    Athletic Performance;    Genotype;    Humans;    PPAR alpha;    Muscle Strength;   

DOI  :  10.5604/20831862.1201051

来源: DOAJ

【 摘 要 】

The performance of professional strength and power athletes is influenced, at least partly, by genetic components. The main aim of this study was to investigate individually and in combination the association ofACE(I/D),ACTN3(R577X) andPPARGC1A(Gly482Ser) gene polymorphisms with strength/power-oriented athletes’ status in two cohorts of European athletes. A cohort of European Caucasians from Russia and Lithuania (161 athletes: by groups – weightlifters (87), powerlifters (60), throwers (14); by elite status – ‘elite’ (104), ‘sub-elite’ (57); and 1,202 controls) were genotyped forACE ,ACTN3andPPARGC1Apolymorphisms. Genotyping was performed by polymerase chain reaction and/or restriction fragment length polymorphism analysis. Statistically significant differences inACTN3(R577X) allele/genotype distribution were not observed in the whole cohort of athletes or between analysed groups separately when compared with controls. The odds ratio for athletes compared to controls of theACEI/I genotype was 1.71 (95% CI 1.01-2.92) in the Russian cohort and for theACEI/D genotype it was 2.35 (95% CI 1.10-5.06) in the Lithuanian cohort. The odds ratio of being a powerlifter inPPARGC1ASer/Ser genotype carriers was 2.11 (95% CI: 1.09-4.09, P = 0.026). TheACTN3(R577X) polymorphism is not associated with strength/power athletic status in two cohorts of European athletes. TheACEI/I genotype is probably the ‘preferable genotype’ for Russian athletes and theACEI/D genotype for Lithuanian strength/power athletes. We found that thePPARGC1A(Gly482Ser) polymorphism is associated with strength/power athlete status. Specifically, thePPARGC1ASer/Ser genotype is more favourable for powerlifters compared to controls.

【 授权许可】

Unknown