A new peptide originated from amphibian skin alleviates the ultraviolet B-induced skin photodamage

Biomedicine & Pharmacotherapy

Yixiang Liu¹  Huiling Sun¹  Meifeng Yang¹  Yingxuan Zhang¹  Ying Wang¹  Naixin Liu¹  Mingying Luo²  Xinwang Yang³  Siyu Wang⁴  Saige Yin⁴  Jiayi Li⁴  Longjun Shu⁴  Zijian Kang⁴  Yue Zhang⁴  Li He⁵ 

[1] Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan 650500, China;;Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission &Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, Yunnan 650504, China;;Department of Anatomy and Histology &;Key Laboratory of Chemistry in Ethnic Medicinal Resources &

关键词: UVB irradiation;    Acute photodamage;    Oxidative stress;    Antioxidant peptide;    Odorrana andersonii;   

DOI  :  

来源: DOAJ

【 摘 要 】

Although amphibian-derived bioactive peptides have attracted increasing attention for their potential use in the treatment of photodamage, research is still in its infancy. In this study, we obtained a new antioxidant peptide, named OA-GI13 (GIWAPWPPRAGLC), from the skin of the odorous frog Odorrana andersonii and determined its effects on ultraviolet B (UVB)-induced skin photodamage as well as its possible molecular mechanisms. Results showed that OA-GI13 directly scavenged free radicals, maintained the viability of hydrogen peroxide-challenged keratinocytes, promoted the release of superoxide dismutase, catalase, and glutathione, and reduced the level of lactate dehydrogenase. Furthermore, topical application of OA-GI13 in mice alleviated dorsal skin erythema and edema and protected the skin against UVB irradiation by increasing antioxidant levels and decreasing peroxide, malondialdehyde, and 8-hydroxydeoxyguanosine levels. OA-GI13 also alleviated oxidative stress injury in vivo and in vitro, possibly by inhibiting p38 protein phosphorylation. Our study confirmed the anti-photodamage effects of this novel amphibian-derived peptide, thus providing a new molecule for the development of drugs and topical agents for the treatment of skin photodamage.

【 授权许可】

Unknown