The relationships between step count and all-cause mortality and cardiovascular events: A dose–response meta-analysis

Journal of Sport and Health Science

Tianzhi Chen¹  Mingxin Sheng²  Xueyu Wu²  Ruixue Cai²  Yiting Liu²  Na Zhang²  Jianqian Chao²  Hongling Chen²  Minqi Liu²  Junyue Yang²  Min Bao²  Bowen Zhang² 

[1] Department of Health Policy and Management, School of Public Health, Peking University, Beijing 100191, China;Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China;

关键词: All-cause death;    Cardiovascular disease;    Daily steps;    Dose-response;    Healthy lifestyle;    Primary prevention;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: A goal of 10,000 steps per day is widely advocated, but there is little evidence to support that goal. Our purpose was to examine the dose–response relationships between step count and all-cause mortality and cardiovascular disease risk. Methods: Cochrane Central Register of Controlled Trials, EMBASE, OVID, PubMed, Scopus, and Web of Science databases were systematically searched for studies published before July 9, 2021, that evaluated the association between daily steps and at least 1 outcome. Results: Sixteen publications (12 related to all-cause mortality, 5 related to cardiovascular disease; and 1 article contained 2 outcomes: both all-cause death and cardiovascular events) were eligible for inclusion in the meta-analysis. There was evidence of a nonlinear dose–response relationship between step count and risk of all-cause mortality or cardiovascular disease (p = 0.002 and p = 0.014 for nonlinearity, respectively). When we restricted the analyses to accelerometer-based studies, the third quartile had a 40.36% lower risk of all-cause mortality and a 35.05% lower risk of cardiovascular event than the first quartile (all-cause mortality: Q1 = 4183 steps/day, Q3 = 8959 steps/day; cardiovascular event: Q1 = 3500 steps/day, Q3 = 9500 steps/day; respectively). Conclusion: Our meta-analysis suggests inverse associations between higher step count and risk of premature death and cardiovascular events in middle-aged and older adults, with nonlinear dose–response patterns.

【 授权许可】

Unknown