Innate Immune Evasion by Human Respiratory Syncytial Virus

Frontiers in Microbiology

Shaowen Hu¹  Yan Hu²  Hongqun Liao³  Huifang Zhu⁴  Kaiyuan Luo⁵  Yan Ouyang⁵ 

[1] Basic Medical College of Gannan Medical University, Ganzhou, China;Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China;Ganzhou Key Laboratory of Immunotherapeutic Drugs Developing for Childhood Leukemia, Ganzhou, China;Institute of Children's Medical, First Affiliated Hospital of Gannan Medical University, Ganzhou, China;Neonatal/Pediatric Intensive Care Unit, Children's Medical Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China;

关键词: respiratory syncytial virus;    innate immune response;    PRRs;    RLRs;    TLRs;    NLRs;   

DOI  :  10.3389/fmicb.2022.865592

来源: DOAJ

【 摘 要 】

Respiratory syncytial virus (RSV) is the leading cause of severe respiratory infection in young children. Nearly all individuals become infected in their early childhood, and reinfections with RSV are common throughout life. Primary infection with RSV is usually involved in the symptom of bronchiolitis and pneumonia in the lower respiratory tract, which accounts for over 3 million hospitalizations and approximately 66,000 deaths annually worldwide. Despite the widespread prevalence and high morbidity and lethality rates of diseases caused by RSV infection, there is currently no licensed RSV vaccine. During RSV infection, innate immunity plays the first line of defense to suppress RSV infection and replication. However, RSV has evolved multiple mechanisms to evade the host’s innate immune responses to gain a window of opportunity for efficient viral replication. This review discusses the comprehensive interaction between RSV infection and the host antiviral innate immunity and updates recent findings on how RSV modulates the host innate immune response for survival, which may provide novel insights to find potent drug targets and vaccines against RSV.

【 授权许可】

Unknown