Development and Characterization of Novel Biopolymer Derived from Abelmoschus esculentus L. Extract and Its Antidiabetic Potential

Molecules

Mohd Adnan¹  Jerold C. Alcantara²  Nagat Elzein Eltoum³  Syed Amir Ashraf³  Abd Elmoneim O. Elkhalifa³  Eyad Al-Shammari³  Amir Mahgoub Awadelkareem³  Mushtaq Ahmad Khan⁴  Khalid Mehmood⁵ 

[1] Department of Biology, College of Science, University of Hail, Hail P.O. Box 2440, Saudi Arabia;Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail P.O. Box 2240, Saudi Arabia;Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail P.O. Box 2440, Saudi Arabia;Department of Microbiology and Immunology, College of Medicine and Health Sciences, UAE University, Al Ain 15551, United Arab Emirates;Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail P.O. Box 81481, Saudi Arabia;

关键词: okra mucilage;    okra polysaccharides;    biopolymer;    α-amylase activity;    α-glucosidase activity;    nutraceuticals;   

DOI  :  10.3390/molecules26123609

来源: DOAJ

【 摘 要 】

Abelmoschus esculentus (Okra) is an important vegetable crop, widely cultivated around the world due to its high nutritional significance along with several health benefits. Different parts of okra including its mucilage have been currently studied for its role in various therapeutic applications. Therefore, we aimed to develop and characterize the okra mucilage biopolymer (OMB) for its physicochemical properties as well as to evaluate its in vitro antidiabetic activity. The characterization of OMB using Fourier-transform infrared spectroscopy (FT-IR) revealed that okra mucilage containing polysaccharides lies in the bandwidth of 3279 and 1030 cm⁻¹, which constitutes the fingerprint region of the spectrum. In addition, physicochemical parameters such as percentage yield, percentage solubility, and swelling index were found to be 2.66%, 96.9%, and 5, respectively. A mineral analysis of newly developed biopolymers showed a substantial amount of calcium (412 mg/100 g), potassium (418 mg/100 g), phosphorus (60 mg/100 g), iron (47 mg/100 g), zinc (16 mg/100 g), and sodium (9 mg/100 g). The significant antidiabetic potential of OMB was demonstrated using α-amylase and α-glucosidase enzyme inhibitory assay. Further investigations are required to explore the newly developed biopolymer for its toxicity, efficacy, and its possible utilization in food, nutraceutical, as well as pharmaceutical industries.

【 授权许可】

Unknown