Molecular Imprinting Technology for Determination of Uric Acid

International Journal of Molecular Sciences

Arunas Ramanavicius¹  Vilma Ratautaite¹  Raimonda Boguzaite¹  Urte Samukaite-Bubniene¹  Deivis Plausinaitis²  Domas Balciunas²  Grażyna Neunert³  Almira Ramanaviciene⁴ 

[1] Department of Functional Materials and Electronics, State Research Institute Centre for Physical Sciences and Technology, Sauletekio Ave. 3, LT-10257 Vilnius, Lithuania;Department of Physical Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania;Department of Physics and Biophysics, Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Wojska Polskiego 38/42, 60-637 Poznań, Poland;NanoTechnas—Nanotechnology and Materials Science Center, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania;

关键词: uric acid;    molecularly imprinted polymers (MIPs);    molecular imprinting technology (MIT);    electrochemical methods;    conducting polymers;    polypyrrole;   

DOI  :  10.3390/ijms22095032

来源: DOAJ

【 摘 要 】

The review focuses on the overview of electrochemical sensors based on molecularly imprinted polymers (MIPs) for the determination of uric acid. The importance of robust and precise determination of uric acid is highlighted, a short description of the principles of molecular imprinting technology is presented, and advantages over the others affinity-based analytical methods are discussed. The review is mainly concerned with the electro-analytical methods like cyclic voltammetry, electrochemical impedance spectroscopy, amperometry, etc. Moreover, there are some scattered notes to the other electrochemistry-related analytical methods, which are capable of providing additional information and to solve some challenges that are not achievable using standard electrochemical methods. The significance of these overviewed methods is highlighted. The overview of the research that is employing MIPs imprinted with uric acid is mainly targeted to address these topics: (i) type of polymers, which are used to design uric acid imprint structures; (ii) types of working electrodes and/or other parts of signal transducing systems applied for the registration of analytical signal; (iii) the description of the uric acid extraction procedures applied for the design of final MIP-structure; (iv) advantages and disadvantages of electrochemical methods and other signal transducing methods used for the registration of the analytical signal; (vi) overview of types of interfering molecules, which were analyzed to evaluate the selectivity; (vi) comparison of analytical characteristics such as linear range, limits of detection and quantification, reusability, reproducibility, repeatability, and stability. Some insights in future development of uric acid sensors are discussed in this review.

【 授权许可】

Unknown