Molecularly Imprinted Polymers: Present and Future Prospective

International Journal of Molecular Sciences

Giuseppe Vasapollo¹  Roberta Del Sole²  Lucia Mergola²  Maria Rosaria Lazzoi²  Anna Scardino²  Sonia Scorrano² 

[1] Department of Engineering of Innovation, University of Salento, via per Arnesano km 1, Lecce 73100, Italy;

关键词: molecularly imprinted polymers (MIPs);    molecular imprinting technology (MIT);    molecular recognition;    solid phase extraction;    sensors;    HPLC;    drug delivery;    catalysis;    artificial receptors;   

DOI  :  10.3390/ijms12095908

来源: mdpi

【 摘 要 】

Molecular Imprinting Technology (MIT) is a technique to design artificial receptors with a predetermined selectivity and specificity for a given analyte, which can be used as ideal materials in various application fields. Molecularly Imprinted Polymers (MIPs), the polymeric matrices obtained using the imprinting technology, are robust molecular recognition elements able to mimic natural recognition entities, such as antibodies and biological receptors, useful to separate and analyze complicated samples such as biological fluids and environmental samples. The scope of this review is to provide a general overview on MIPs field discussing first general aspects in MIP preparation and then dealing with various application aspects. This review aims to outline the molecularly imprinted process and present a summary of principal application fields of molecularly imprinted polymers, focusing on chemical sensing, separation science, drug delivery and catalysis. Some significant aspects about preparation and application of the molecular imprinting polymers with examples taken from the recent literature will be discussed. Theoretical and experimental parameters for MIPs design in terms of the interaction between template and polymer functionalities will be considered and synthesis methods for the improvement of MIP recognition properties will also be presented.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.