Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer

Nutrients

Miklos Fogarasi¹  Alexa Lisevick¹  Tara Sanft²  Brenda Cartmel³  Maura Harrigan³  Melinda L. Irwin³  Fangyong Li³  Leah M. Ferrucci³ 

[1] Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, CT 06518, USA;Yale Cancer Center, New Haven, CT 06510, USA;Yale School of Public Health, Yale University, New Haven, CT 06510, USA;

关键词: breast cancer;    survivorship;    weight loss maintenance;    lifestyle intervention;   

DOI  :  10.3390/nu13093265

来源: DOAJ

【 摘 要 】

Lifestyle interventions among breast cancer survivors with obesity have demonstrated successful short-term weight loss, but data on long-term weight maintenance are limited. We evaluated long-term weight loss maintenance in 100 breast cancer survivors with overweight/obesity in the efficacious six-month Lifestyle, Exercise, and Nutrition (LEAN) Study (intervention = 67; usual care = 33). Measured baseline and six-month weights were available for 92 women. Long-term weight data were obtained from electronic health records. We assessed weight trajectories between study completion (2012–2013) and July 2019 using growth curve analyses. Over up to eight years (mean = 5.9, SD = 1.9) of post-intervention follow-up, both the intervention (n = 60) and usual care (n = 32) groups declined in body weight. Controlling for body weight at study completion, the yearly weight loss rate in the intervention and usual care groups was –0.20 kg (−0.2%/year) (95% CI: 0.06, 0.33, p = 0.004) and −0.32 kg (−0.4%/year) (95% CI: 0.12, 0.53, p = 0.002), respectively; mean weight change did not differ between groups (p = 0.31). It was encouraging that both groups maintained their original intervention period weight loss (6% intervention, 2% usual care) and had modest weight loss during long-term follow-up. Breast cancer survivors in the LEAN Study, regardless of randomization, avoided long-term weight gain following study completion.

【 授权许可】

Unknown