Change in the Prevalences and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia in Korea: Multicenter Clinical Trials

The Korean Journal of Helicobacter and Upper Gastrointestinal Research

Hyeon Ju Kim¹  Hyun Jin Kim²  Young-Eun Joo³  Dae-Seong Myung³  Gwang Ho Baik⁴  Kwangwoo Nam⁵  Jeong Eun Shin⁵  Hyun Joo Song⁶  Heung Up Kim⁶  Kyung Sik Park⁷  Ju Yup Lee⁷  Sung Eun Kim⁸  Gwang Ha Kim⁹  Jongchan Lee^1,10  Young-Jae Hwang^1,10  Nayoung Kim^1,10  Seon Hee Lim^1,11  Geom Seog Seo^1,12  Suck Chei Choi^1,12 

[1] Department of Family Medicine, Jeju National University School of Medicine, Jeju, Korea;Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea;Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea;Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Korea;Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea;Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea;Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea;Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea;Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea;Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea;Department of Internal Medicine, Seoul National University Healthcare System Gangnam Center and Healthcare Research Institute, Seoul, Korea;Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea;

关键词: Atrophic gastritis;    Helicobacter pylori;    Metaplasia;    Prevalence;    Risk factors;   

DOI  :  10.7704/kjhugr.2018.18.4.247

来源: DOAJ

【 摘 要 】

Background/Aims: The aim of this study was to analyze the trend of the prevalences of atrophic gastritis (AG) and intestinal metaplasia (IM) from 2011 to 2016∼2017 in Korea. And, the risk factors of AG and IM were compared between 2011 and 2016∼2017. Materials and Methods: A total of 4,023 subjects in 2011 and 2,506 subjects in 2016∼2017 were enrolled. AG and IM were diagnosed on the basis of endoscopic findings. Multivariate analysis was performed for risk factors of AG and IM. Seventeen factors were analyzed. Results: The seroprevalence of Helicobacter pylori decreased from 2011 (59.8%; 2,407/4,023) to 2016∼2017 (51.6%; 1,293/2,506; P＜ 0.001). The prevalence of AG decreased from 2011 to 2016∼2017 (P=0.018), but that of IM increased (P＜ 0.001). The risk factors of AG in 2011 were male sex, old age, H. pylori immuoglobulin G (IgG) positivity, family history of gastric cancer (GC), and high-salt diet. For IM in 2011, the risk factors were male sex, old age, H. pylori IgG positivity, and family history of GC. Risk factors of AG in 2016∼2017 were old age, H. pylori IgG positivity, and country of residence. For IM in 2016∼2017, the risk factors were male sex, old age, family history of GC, high fasting glucose level (≥126 mg/dL), H. pylori IgG positivity, and low income level. Conclusions: The difference in prevalence trends of AG and IM between 2016∼2017 and 2011 could be the result of the different risk factors of AG and IM, such as decreased prevalence of H. pylori infection.

【 授权许可】

Unknown