Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease

Frontiers in Neurology

Isabel Pavão Martins¹  Joaquim J. Ferreira²  Rita Simões²  Inês Chendo³  Margherita Fabbri⁴  Catarina Godinho⁵  Catarina Severiano e Sousa⁶  Miguel Coelho⁹ 

[1] 0Laboratório de Estudos da Linguagem, Instituto de Medicina Molecular de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal;Campus Neurológico Sénior, Torres Vedras, Portugal;Clínica Universitária de Psiquiatria, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal;Department of Neurosciences, Clinical Investigation Center 1436, Parkinson Toulouse Expert Center, NS-Park/FCRIN Network and NeuroToul COEN Center, Toulouse University Hospital, INSERM, University of Toulouse 3, Toulouse, France;Grupo de Patologia Médica, Nutrição e Exercício Clínico do Centro de Investigação Interdisciplinar Egas Moniz, Escola Superior de Saúde Egas Moniz, Almada, Portugal;Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal;Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal;Neurology Department, Hospital Beatriz Ângelo, Loures, Portugal;Neurology Service, Department of Neurosciences, Hospital Santa Maria, Lisbon, Portugal;Psychiatry Department, Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal;

关键词: Parkinson's disease;    late-stage;    dementia;    cognitive impairment;    diagnostic criteria;   

DOI  :  10.3389/fneur.2021.652424

来源: DOAJ

【 摘 要 】

Background: Cognitive impairment is a potential late feature of Parkinson's disease (PD). However, studies in patients with late-stage PD are lacking due to the particular characteristics of this population.Objectives: To evaluate the frequency of dementia in late-stage PD patients and to assess the impact of using different diagnostic criteria.Methods: We conducted a cross-sectional study to estimate the frequency of dementia in late-stage PD patients using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria as the primary outcome. We also applied other diagnostic criteria [MDS (Level I), DSM-IV, and DSM-5 criteria] to determine their applicability and impact on dementia frequency.Results: 93 participants with a mean age of 75.8 years (SD 6.8) and 16.5 years (SD 7.5) of disease duration were included. 64.3% were classified as demented using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria. We observed a high discrepancy on the frequency of dementia depending on the criteria applied [6.2% with MDS (Level I), 58.8% with DSM-IV, and 72.0% with DSM-5 criteria].Conclusions: We found a frequency of dementia below what was observed in similar populations. The particular characteristics of our sample may have contributed as protective factors for late-stage dementia. Dementia frequency varied depending on the criteria used mainly due to the presence of major depression.

【 授权许可】

Unknown