Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

Frontiers in Immunology

Laura Migliari Branco¹  Karina R. Bortoluci¹  Sandy Adjemian⁴  Larissa C. Zanetti⁵  Ricardo Weinlich⁵  Gustavo P. Amarante-Mendes⁶ 

[1] Centro de Terapia Celular e Molecular (CTC-Mol), Universidade Federal de São Paulo, São Paulo, Brazil;Departamento de Ciências Biológicas, Universidade Federal de São Paulo, Diadema, Brazil;Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil;Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium;Instituto Israelita de Ensino e Pesquisa, Hospital Israelita Albert Einstein, São Paulo, Brazil;Instituto de Investigação em Imunologia, Instituto Nacional de Ciência e Tecnologia (INCT), São Paulo, Brazil;Molecular Signaling and Cell Death Unit, Inflammation Research Center, VIB, Ghent, Belgium;

关键词: PRR;    pathogen recognition receptor;    apoptosis;    necroptosis;    pyroptosis;    inflammation;   

DOI  :  10.3389/fimmu.2018.02379

来源: DOAJ

【 摘 要 】

Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns—PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular Patterns—DAMPs). They emerged phylogenetically prior to the appearance of the adaptive immunity and, therefore, are considered part of the innate immune system. Signals derived from the engagement of PRRs on the immune cells activate microbicidal and pro-inflammatory responses required to eliminate or, at least, to contain infectious agents. Molecularly controlled forms of cell death are also part of a very ancestral mechanism involved in key aspects of the physiology of multicellular organism, including the elimination of unwanted, damaged or infected cells. Interestingly, each form of cell death has its particular effect on inflammation and on the development of innate and adaptive immune responses. In this review article, we discuss some aspects of the molecular interplay between the cell death machinery and signals initiated by the activation of PRRs by PAMPs and DAMPs.

【 授权许可】

Unknown