Exploring Brain Derived Neurotrophic Factor and Cell Adhesion Molecules as Biomarkers for the Transdiagnostic Symptom Anhedonia in Alcohol Use Disorder and Comorbid Depression

Frontiers in Psychiatry

Anastasiia S. Boiko¹  Arnt F. A. Schellekens²  Elise M. G. Meeder²  Nikolay A. Bokhan³  German G. Simutkin³  Elena V. Epimakhova³  Innokentiy S. Losenkov³  Lyudmila A. Levchuk³  Olga V. Roschina³  Ekaterina V. Michalitskaya³  Svetlana A. Ivanova⁴  Anton J. M. Loonen⁵ 

[1] Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands;Department of Psychiatry, Donders Institute for Brain, Cognition, and Behavior, Radboudumc, Nijmegen, Netherlands;Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia;Nijmegen Institute for Scientist-Practitioners in Addiction (NISPA), Radboud University Nijmegen, Nijmegen, Netherlands;;Unit of PharmacoTherapy, Epidemiology, &

关键词: biomarker;    transdiagnostic;    brain-derived neurotrophic factor;    cell adhesion molecule;    depressive disorder;    addiction;   

DOI  :  10.3389/fpsyt.2020.00296

来源: DOAJ

【 摘 要 】

BackgroundAlcohol Use Disorder (AUD) and depressive disorder often co-exist and have a shared heritability. This study aimed to investigate Brain-Derived Neurotrophic Factor (BDNF) and three Cell Adhesion Molecules (CAMs) as transdiagnostic biomarkers in AUD and depression co-morbidity.MethodsIn a cross-sectional study, patients with AUD (n=22), AUD and depression (n=19), and healthy controls (n=20) were examined. Depression and anxiety severity were assessed using the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale. Anhedonia, alcohol use and dependence, craving, and social adaptation were assessed through self-report questionnaires. BDNF and CAM concentrations in peripheral serum were measured after overnight fasting using a Luminex assay. After controlling for age and gender, biomarker levels were compared across groups. The association between biomarker concentrations and symptom severity scales were explored using correlation and multiple regression analyses.ResultsBDNF and Neuronal CAM were lower in patients with AUD with and without depression compared to healthy controls. No differences were observed for Vascular CAM-1 and Interstitial CAM-1. BDNF correlated negatively with anhedonia levels. BDNF, age and gender together explained 21% of variability in anhedonia levels.ConclusionThis pilot study suggests that peripheral levels of BDNF and NCAM might be reduced in AUD with and without comorbid mood disorder. Since low BDNF levels were associated with self- reported anhedonia across these conditions, BDNF and anhedonia might reflect transdiagnostic aspects involved in AUD and depression.

【 授权许可】

Unknown