The Emerging Role of BDNF/TrkB Signaling in Cardiovascular Diseases

Life

Feng-Qin Ge¹  Hua Zhu¹  Peng-Zhou Hang¹  Zhi-Min Du²  Jie Liu²  Pei-Feng Li²  Jing Zhao³ 

[1] Department of Pharmacy, Clinical Medical College, Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou 225001, China;Institute of Clinical Pharmacology, The Second Affiliated Hospital of Harbin Medical University (University Key Laboratory of Drug Research), Harbin 150086, China;Medical Research Center, Clinical Medical College, Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou 225001, China;

关键词: brain-derived neurotrophic factor;    tropomyosin-related kinase receptor B;    cardiovascular diseases;    biomarker;   

DOI  :  10.3390/life11010070

来源: DOAJ

【 摘 要 】

Brain-derived neurotrophic factor (BDNF) is one of the most abundantneurotrophins in the central nervous system. Numerous studies suggestthat BDNF has extensive roles by binding to its specific receptor, tropomyosin-related kinase receptor B (TrkB), and thereby triggering downstream signaling pathways. Recently, growing evidence highlightsthat the BDNF/TrkB pathway is expressed in the cardiovascular system andclosely associated with the development and outcome of cardiovascular diseases (CVD), including coronary artery disease, heart failure, cardiomyopathy, hypertension, and metabolic diseases. Furthermore, circulating BDNF has also been revealed as a new potential biomarker for both diagnosis and prognosis of CVD. In this review, we discuss the current evidence of the emerging role of BDNF/TrkBsignalingand address the challenges that remain in translating these discoveries to novel therapeutic strategies for CVD.

【 授权许可】

Unknown