New Indole Glycosides from Aesculus chinensis var. chekiangensis and Their Neuroprotective Activities

Molecules

Pan Li¹  Feng Qiu¹  Weixing Huang¹  Ning Kang¹  Nan Zhang¹  Shijie Cao²  Liqin Ding² 

[1] School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;

关键词: aesculus chinensis bge. var. chekiangensis (hu et fang) fang;    n-glucosylated indoles;    neuroprotective activity;   

DOI  :  10.3390/molecules24224063

来源: DOAJ

【 摘 要 】

The dried seeds of Aesculus chinensis Bge. var. chekiangensis (Hu et Fang) Fang, called “Suo Luo Zi”, have been used in traditional Chinese medicine. Nevertheless, most studies have been focused on components of less polarity fractions. In this research, twelve indoles, including six new indole glycosides (1−6) as well as six known analogs were isolated from the polar portion which has been seldom studied. This is the first description of N-glucosylated indoles obtained from the genus of Aesculus. Structures of the new compounds (1−6) were elucidated based on comprehensive interpretation of HRESIMS, 1D and 2D NMR. Additionally, the neuroprotective activities of the N-glucosylated indoles were evaluated for the first time indicating that compounds 1−5 and 9−10 exhibited moderate neuroprotective activities. Further cytotoxicity tests of isolates 1−10 on three human tumor cell lines suggested that none of these compounds were cytotoxic (IC₅₀ > 50 μM).

【 授权许可】

Unknown