Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides

Marine Drugs

Chiung-Yao Huang²  Jui-Hsin Su²  Bo-Wei Chen²  Zhi-Hong Wen²  Chi-Hsin Hsu²  Chang-Feng Dai¹  Jyh-Horng Sheu² 

[1] Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:

关键词: soft coral;    Paralemnalia thyrsoides;    nardosinane;    neuroprotective activity;   

DOI  :  10.3390/md9091543

来源: mdpi

【 摘 要 】

Five new nardosinane-type sesquiterpenoids, paralemnolins Q–U (1–5), along with three known compounds (6–8), were isolated from the Formosan soft coral Paralemnalia thyrsoides. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods, and the absolute configuration of 1 was determined by the application of Mosher’s method on 1. Among these metabolites, 1 and 3 are rarely found nardosinane-type sesquiterpenoids, possessing novel polycyclic structures. Compounds 1, 3, 6 and 7 were found to possess neuroprotective activity.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland