Clavukoellians G–K, New Nardosinane and Aristolane Sesquiterpenoids with Angiogenesis Promoting Activity from the Marine Soft Coral Lemnalia sp.

Marine Drugs

Xuli Tang¹  Pinglin Li²  Xiangchao Luo²  Guoqiang Li²  Qi Wang²  Hui Liu²  PingJyun Sung³ 

[1] College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China;Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan;

关键词: lemnalia sp.;    clavukoellian;    nardosinane;    aristolane;    sesquiterpenoid;    angiogenesis promoting activity;   

DOI  :  10.3390/md18030171

来源: DOAJ

【 摘 要 】

The chemical examination of the marine soft coral Lemnalia sp., collected at the Xisha islands in the South China Sea, resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely clavukoellians G−J (1−4), and one new aristolane sesquiterpene, namely clavukoellian K (5), together with five known compounds, 6−10. The structure elucidation of the isolated natural products was based on various spectroscopic techniques including HRESIMS and NMR, while their absolute configurations were resolved on the basis of comparisons of the ECD spectra with the calculated ECD data. The isolated new compounds 1−5 were evaluated for their anti- and pro- angiogenesis activities in a transgenic fluorescent zebrafish (Tg(vegfr2:GFP)) model. Quantitative analysis revealed that compound 5 displayed pro-angiogenesis activity in a PTK787-induced vascular injury zebrafish model at 2.5 μM. Data showed that compound 5 significantly promoted the angiogenesis in a dose-dependent manner.

【 授权许可】

Unknown