Epigenetic regulation of retinal development

Epigenetics & Chromatin

Alexandre Hiroaki Kihara¹  Merari F. R. Ferrari²  Reza Raeisossadati²  Jeffrey M. Gross³  Issam AlDiri³ 

[1] Centro de Matemática, Computação E Cognição, Universidade Federal Do ABC;Departamento de Genética E Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo;Departments of Ophthalmology and Developmental Biology, Louis J. Fox Center for Vision Restoration, University of Pittsburgh School of Medicine;

关键词: Epigenetics;    Retina;    Histone;    DNA methylation;    lncRNA;    Development;   

DOI  :  10.1186/s13072-021-00384-w

来源: DOAJ

【 摘 要 】

Abstract In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determination and terminal differentiation are controlled by intricate crosstalk between the genome and epigenome. Indeed, epigenetic regulation plays pivotal roles in numerous cell fate specification and differentiation events in the retina. Moreover, aberrant chromatin structure can contribute to developmental disorders and retinal pathologies. In this review, we highlight recent advances in our understanding of epigenetic regulation in the retina. We also provide insight into several aspects of epigenetic-related regulation that should be investigated in future studies of retinal development and disease. Importantly, focusing on these mechanisms could contribute to the development of novel treatment strategies targeting a variety of retinal disorders.

【 授权许可】

Unknown