β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms

Journal of Functional Foods

Mujić Ibrahim¹  Vidaković Melita²  Poznanović Goran²  Mihailović Mirjana²  Arambašić Jelena²  Dinić Svetlana²  Grdović Nevena²  Uskoković Aleksandra²  Marković Jelena²  Šijački D. Ana³ 

[1] Biotechnical Faculty, University of Bihać, Kulina Bana 2, 77000 Bihać, Bosnia and Herzegovina;Department of Molecular Biology, Institute for Biological Research, University of Belgrade, Bulevar Despota Stefana 142, 10060 Belgrade, Serbia;Medical Faculty, University of Belgrade, Clinical Center of Serbia, Dr. Subotića 8, 11000 Belgrade, Serbia;

关键词: Diabetes;    β-Glucan;    Antioxidant activities;    Akt kinase;    Pro-survival pathways;   

DOI  :  

来源: DOAJ

【 摘 要 】

The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications.

【 授权许可】

Unknown