High incidence and persistence of hepatitis B virus infection in individuals receiving HIV care in KwaZulu-Natal, South Africa

BMC Infectious Diseases

Jerome Amir Singh¹  Salim Abdool-Karim¹  Quarraisha Abdool-Karim¹  Kogieleum Naidoo¹  Nesri Padayatchi¹  Nonhlanhla Yende-Zuma¹  Nokukhanya Msomi²  Kerusha Govender²  Koleka Mlisana³ 

[1] Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal;Discipline of Virology-University of KwaZulu-Natal, School of Laboratory Medicine and Medical Sciences and National Health Laboratory Service;National Health Laboratory Service and School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal;

关键词: HBV incidence;    HIV/HBV coinfection;    South Africa;   

DOI  :  10.1186/s12879-020-05575-6

来源: DOAJ

【 摘 要 】

Abstract Background Hepatitis B virus (HBV), Human Immunodeficiency virus (HIV) and Tuberculosis (TB) are common infections in South Africa. We utilized the opportunity of care provision for HIV-TB co-infected patients to better understand the relationship between these coinfections, determine the magnitude of the problem, and identify risk factors for HBV infection in HIV infected patients with and without TB in KwaZulu-Natal, South Africa. Methods This retrospective cohort analysis was undertaken in 2018. In-care HIV infected patients were included in the analysis. Results from clinical records were analysed to determine the prevalence, incidence, persistence and factors associated with HBsAg positivity in HIV-infected patients with or without TB co-infection. Results A total of 4292 HIV-infected patients with a mean age of 34.7 years (SD: 8.8) were included. Based on HBsAg positivity, the prevalence of HBV was 8.5% (363/4292) [95% confidence interval (CI): 7.7–9.3] at baseline and 9.4% (95%CI: 8.6–10.3%) at end of follow-up. The HBV incidence rate was 2.1/100 person-years (p-y). Risk of incident HBV infection was two-fold higher among male patients (HR 2.11; 95% CI: 1.14–3.92), while severe immunosuppression was associated with a greater than two-fold higher risk of persistent infection (adjusted risk ratio (RR) 2.54; 95% CI 1.06–6.14; p = 0.004. Additionally, active TB at enrolment was associated with a two-fold higher risk of incident HBV infection (aHR 2.38; 95% CI: 0.77–7.35). Conclusion The provision of HIV care and treatment in high HBV burden settings provide a missed opportunity for HBV screening, immunization and care provision.

【 授权许可】

Unknown