tcpC as a prospective new virulence marker in blood Escherichia coli isolates from sepsis patients admitted to the intensive care unit

New Microbes and New Infections

R. Gaind¹  R.S. Dhanda²  M. Yadav³  D. Nagarjuna³ 

[1] Department of Microbiology, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, Delhi, India;Department of Translational and Regenerative medicine, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India;Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, India;

关键词: Escherichia coli;    phylogroups;    sepsis;    tcpC;    virulence factor;   

DOI  :  10.1016/j.nmni.2015.05.002

来源: DOAJ

【 摘 要 】

The prevalence of the tcpC in the blood Escherichia coli isolates collected from the sepsis patients admitted to the intensive care unit was investigated for the first time. The blood and faecal samples were collected from sepsis and nonsepsis patients, respectively. The prevalence of the tcpC and phylogroups was confirmed by gene-specific PCR. The occurrence of the tcpC in the blood E. coli isolates from sepsis patients was significantly higher than the faecal isolates. The higher prevalence of blood E. coli isolates among the pathogenic groups (B2, D) compared to the commensal groups (A, B1) suggests tcpC as a prospective new virulence marker for sepsis.

【 授权许可】

Unknown