Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery

Nutrients

Yin-Tzu Huang¹  Ping-Ting Lin¹  Yi-Chia Huang¹  Shao-Bin Cheng²  Hsiao-Tien Liu² 

[1] Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan;Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan;

关键词: coenzyme Q10;    oxidative stress;    inflammation;    hepatocellular carcinoma;    surgery;   

DOI  :  10.3390/nu9010029

来源: DOAJ

【 摘 要 】

(1) Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide, and surgical resection is the main treatment for HCC. To date, no published study has examined the status of coenzyme Q10 in patients with HCC after surgery. Thus, the purpose of this study was to investigate the correlations between the level of coenzyme Q10, oxidative stress, and inflammation in patients with HCC after surgery; (2) Methods: 71 primary HCC patients were recruited. Levels of coenzyme Q10, vitamin E, oxidative stress (malondialdehyde), antioxidant enzymes activity (superoxidase dismutase, catalase, and glutathione peroxidase), and inflammatory markers (high sensitivity C-reactive protein; tumor necrosis factor-α; and interleukin-6) were measured; (3) Results: Patients with HCC had a significantly lower levels of coenzyme Q10 (p = 0.01) and oxidative stress (p < 0.01), and significantly higher levels of antioxidant enzymes activities and inflammation after surgery (p < 0.05). The level of coenzyme Q10 was significantly positively correlated with antioxidant capacity (vitamin E and glutathione peroxidase activity) and negatively correlated with inflammation markers after surgery; (4) Conclusion: Hepatocarcinogenesis is associated with oxidative stress, and coenzyme Q10 may be considered an antioxidant therapy for patients with HCC, particularly those with higher inflammation after surgery.

【 授权许可】

Unknown