Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus

Healthcare

Qiuhua Shen¹  Janet D. Pierce²  Samir Samman² 

[1] School of Nursing, University of Kansas, 3901 Rainbow Blvd., Mailstop 4043, Kansas City, KS 66160, USA; E-Mail

关键词: type 2 diabetes mellitus;    coenzyme Q10;    mitochondrial dysfunction;    oxidative stress;    antioxidant;    adenosine triphosphate;   

DOI  :  10.3390/healthcare3020296

来源: mdpi

【 摘 要 】

Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality with ever increasing prevalence in the United States and worldwide. There is growing body of evidence suggesting that mitochondrial dysfunction secondary to oxidative stress plays a critical role in the pathogenesis of T2DM. Coenzyme Q10 is an important micronutrient acting on the electron transport chain of the mitochondria with two major functions: (1) synthesis of adenosine triphosphate (ATP); and (2) a potent antioxidant. Deficiency in coenzyme Q10 is often seen in patients with T2DM. Whether restoration of coenzyme Q10 will help alleviate oxidative stress, preserve mitochondrial function, and thus improve glycemic control in T2DM is unclear. This article reviews the relationships among oxidative stress, mitochondrial dysfunction, and T2DM and examines the evidence for potential use of coenzyme Q10 as a supplement for the treatment of T2DM.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.