INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division

Cell Reports

Devin A. King¹  Ka Man Wong¹  Graeme J. Gowans¹  Ashby J. Morrison¹  Alicia N. Schep²  William J. Greenleaf² 

[1] Department of Biology, Stanford University, Stanford, CA 94305, USA;Department of Genetics, Stanford University, Stanford, CA 94305, USA;

关键词: INO80;    chromatin;    metabolism;    yeast metabolic cycle;    cell division;    TORC1;    Arp5;    Msn2/4;    Reb1;    Abf1;   

DOI  :  10.1016/j.celrep.2017.12.079

来源: DOAJ

【 摘 要 】

Adaptive survival requires the coordination of nutrient availability with expenditure of cellular resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes synchronize and exhibit periodic bursts of expression in coordination with respiration and cell division in the yeast metabolic cycle (YMC). Despite the importance of metabolic and proliferative synchrony, the majority of YMC regulators are currently unknown. Here, we demonstrate that the INO80 chromatin-remodeling complex is required to coordinate respiration and cell division with periodic gene expression. Specifically, INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. In mutant cells, chromatin accessibility of periodic genes, including TORC1-responsive genes, is relatively static, concomitant with severely attenuated gene expression. Collectively, these results reveal that the INO80 complex mediates metabolic signaling to chromatin to restrict proliferation to metabolically optimal states.

【 授权许可】

Unknown