A sulfated polysaccharide from the edible flesh of Cipangopaludina chinensis inhibits angiogenesis to enhance atherosclerotic plaque stability

Journal of Functional Foods

Ziyun Zhang¹  Li Zhou²  Guoqing Qian²  Tingting Xu³  Hailun Li³  Jian Liang⁴  Yi Jing⁵  Yun Han⁶  Yingying Shi⁷  Qingping Xiong⁷  Jun Yuan⁷  Youdong Hu⁸ 

[1] Corresponding authors at: Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai’an, Jiangsu, China (Q. Xiong, G. Qian and J. Yuan).;Local Joint Engineering Research Center for Mineral Salt Deep Utilization, Huaiyin Institute of Technology, Huaian 223003, China;;National &School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;Department of Intensive Care Unit, Dazhou Central Hospital, Dazhou 635000, Sichuan, China;Department of Nephrology, Huai’an Second People’s Hospital, Huai’an 223002, Jiangsu, China;Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai’an 223003, Jiangsu, China;School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;

关键词: Sulfated polysaccharides;    Cipangopaludina chinensis;    Stability of atherosclerotic plaque;    Angiogenesis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Sulfated polysaccharide (CCPSs) of Cipangopaludina chinensis has shown significant antiangiogenic activity. In view of the closely relationship between angiogenesis and atherosclerotic plaque vulnerability, we speculated that CCPSs may stabilize atherosclerotic plaques by inhibiting angiogenesis. The purpose of this study was to demonstrate a correlation between the role of CCPSs in stabilizing plaques and its inhibition of angiogenesis, and further clarify its regulatory mechanism. The results suggested that CCPSs can enhance the stable components and inhibit the vulnerability factors to reduce vulnerability index of atherosclerotic plaques, thus making it more stable. Its mechanism was proved to be closely related with anti-angiogenesis in plaques. This inhibitory effect of CCPSs on angiogenesis in plaques was also found to be achieved by regulating the PI3K/Akt/mTOR signaling pathway. The results indicated that CCPSs is a promising candidate for treatment of atherosclerotic unstable plaques.

【 授权许可】

Unknown