Mechanobiology of the female reproductive system

Reproductive Medicine and Biology

Sachiko Matsuzaki¹ 

[1] CHU Clermont‐Ferrand Chirurgie Gynécologique Clermont‐Ferrand France;

关键词: Embryo;    Female reproductive system;    Mechanobiology;    Ovary;    Uterus;   

DOI  :  10.1002/rmb2.12404

来源: DOAJ

【 摘 要 】

Abstract Background Mechanobiology in the field of human female reproduction has been extremely challenging technically and ethically. Methods The present review provides the current knowledge on mechanobiology of the female reproductive system. This review focuses on the early phases of reproduction from oocyte development to early embryonic development, with an emphasis on current progress. Main findings (Results) Optimal, well‐controlled mechanical cues are required for female reproductive system physiology. Many important questions remain unanswered; whether and how mechanical imbalances among the embryo, decidua, and uterine muscle contractions affect early human embryonic development, whether the biomechanical properties of oocytes/embryos are potential biomarkers for selecting high‐quality oocytes/embryos, whether mechanical properties differ between the two major compartments of the ovary (cortex and medulla) in normally ovulating human ovaries, whether durotaxis is involved in several processes in addition to embryonic development. Progress in mechanobiology is dependent on development of technologies that enable precise physical measurements. Conclusion More studies are needed to understand the roles of forces and changes in the mechanical properties of female reproductive system physiology. Recent and future technological advancements in mechanobiology research will help us understand the role of mechanical forces in female reproductive system disorders/diseases.

【 授权许可】

Unknown