NEW METHODS OF OPTIMIZATION OF EPILEPSY PHARMACOTHERAPY: USE OF BAYESIAN PHARMACOKINETIC MODELING

Эпилепсия и пароксизмальные состояния

L. А. Mota¹  M. V. Shiryaeva¹  Z. А. Suslina¹  V. V. Shvedkov¹  D. I. Prokhorov¹  D. А. Аbaimov¹  R. D. Sejfulla¹  А. K. Sariev¹  T. YU. Noskova¹ 

[1] Russian Academy of Medical Science, Scientific Center of Neurology of RAMN;

关键词: therapeutic drug monitoring (tdm);    carbamazepine;    epilepsy;    pharmacokinetics;    a range of therapeutic concentration;    computer program mm-uscpack;   

DOI  :  

来源: DOAJ

【 摘 要 】

There was carried out the therapeutic drug monitoring of antiepileptic drug carbamazepine by use of a bayesian mathematical modeling method in 47 patients with a focal epilepsy. The database of patients pharmacokinetic characteristics concerning carbamazepine was created. According the results of carbamazepine monitoring anticonvulsant dosage regimen was corrected

【 授权许可】

Unknown