Zika Virus

Pathogens

Pradip Dashraath¹  Didier Musso²  Leo Pomar³  Milos Stojanov³  David Baud³  Sophie Masmejan³  Manon Vouga³  Alice Panchaud⁴ 

[1]Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, National University Hospital, Singapore 119074, Singapore

[2]Laboratoire Eurofins Labazur Guyane, 97300 Cayenne, French Guiana

[3]Maternofetal and Obstetrics Research Unit, Department “Woman-Mother-Child”, University Hospital, 1011 Lausanne, Switzerland

[4]Service of Pharmacy, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland

关键词: Zika;    Zika virus;    emerging infectious diseases;    congenital Zika syndrome;    materno-fetal infections;    Guillain-Barré syndrome;   

DOI  :  10.3390/pathogens9110898

来源: DOAJ

【 摘 要 】

Zika virus (ZIKV), a neurotropic single-stranded RNA flavivirus, remains an important cause of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in populations where ZIKV has adapted to a nexus involving the Aedes mosquitoes and humans. To date, outbreaks of ZIKV have occurred in Africa, Southeast Asia, the Pacific islands, the Americas, and the Caribbean. Emerging evidence, however, suggests that the virus also has the potential to cause infections in Europe, where autochtonous transmission of the virus has been identified. This review focuses on evolving ZIKV epidemiology, modes of transmission and host-virus interactions. The clinical manifestations, diagnostic issues relating to cross-reactivity to the dengue flavivirus and concerns surrounding ZIKV infection in pregnancy are discussed. In the last section, current challenges in treatment and prevention are outlined.

【 授权许可】

Unknown