Ultraviolet spectrophotometric methods for the determination of the minor component presented in fixed-dose pharmaceutical combinations through the last two decades (2000–2020)

Future Journal of Pharmaceutical Sciences

Amir Alhaj Sakur¹  Duaa J. Al Zakri¹  Reem H. Obaydo¹  Hayam M. Lotfy² 

[1] Department of Analytical and Food Chemistry, Faculty of Pharmacy, University of Aleppo;Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Science and Pharmaceutical Industries, Future University in Egypt;

关键词: Fixed-dose combinations drug;    Minor component;    Ultraviolet spectrophotometric methods;   

DOI  :  10.1186/s43094-021-00192-9

来源: DOAJ

【 摘 要 】

Abstract Background The pharmaceutical industry and the National Regulatory Authorities are now focusing on the quantification of multi-component drugs for quality control testing. Main body Recently, the utilization of the ultraviolet spectrophotometric methods has become vital for the analytical studies for the routine analysis of different fixed-dose combination products either in the presence of a minor component in their combination or not. This article reviewed several published methods to those that have been applied to quantify some pharmaceutical combinations containing minor components through the last two decades. Conclusion The applied spectrophotometric methods are labor, time-saving, and also considered a cheap substitute for the overpriced high-performance liquid chromatographic technique.

【 授权许可】

Unknown