Using Chitosan or Chitosan Derivatives in Cancer Therapy

Polysaccharides

Mahruba Sultana Niloy¹  Md. Forhad Uddin¹  Kazi Mustafa Mahmud¹  Md. Ashraful Hasan¹  Sajal Kumar Halder¹  Mohammad Sayem²  Md. Sakib Hossen²  Md Salman Shakil³ 

[1] Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;Department of Biochemistry, Primeasia University, Banani, Dhaka 1213, Bangladesh;Department of Pharmacology and Toxicology, University of Otago, Dunedin 9016, New Zealand;

关键词: chitosan;    chitosan derivatives;    anticancer activities;    gene and drug delivery;    immunotherapy;   

DOI  :  10.3390/polysaccharides2040048

来源: DOAJ

【 摘 要 】

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

【 授权许可】

Unknown