Clinical Profiles in Renal Patients with COVID-19

Journal of Clinical Medicine

Roberto Güerri-Fernández¹  JuanPablo Horcajada¹  MaríaMilagro Montero¹  Judith Villar-García¹  Marta Crespo²  Isabel Galcerán²  Sara Outón²  Francesc Barbosa²  Julio Pascual²  Eulalia Solá²  Carlos Arias-Cabrales²  Adriana Sierra²  Higini Cao²  Laia Sans²  Laura Llinàs-Mallol²  MaríaJosé Pérez-Sáez²  MaríaDolores Arenas²  Anna Oliveras²  Silvia Collado²  Carla Burballa²  Susana Vázquez²  Marisa Mir²  Anna Buxeda²  Dolores Redondo-Pachón²  Clara Barrios²  Eva Rodríguez² 

[1] Department of Infectious Diseases, Hospital del Mar, 08003 Barcelona, Spain;Department of Nephrology, Hospital del Mar, 08003 Barcelona, Spain;

关键词: COVID-19;    SARS-CoV-2;    RT-PCR;    kidney transplantation;    hemodialysis;    pneumonia;   

DOI  :  10.3390/jcm9082665

来源: DOAJ

【 摘 要 】

The COVID-19 pandemic has led to frequent referrals to the emergency department on suspicion of this infection in maintenance hemodialysis (MHD) and kidney transplant (KT) patients. We aimed to describe their clinical features comparing confirmed and suspected non-confirmed COVID-19 cases during the Spanish epidemic peak. Confirmed COVID-19 ((+)COVID-19) corresponds to patient with positive RT-PCR SARS-CoV-2 assay. Non-confirmed COVID-19 ((−)COVID-19) corresponds to patients with negative RT-PCR. COVID-19 was suspected in 61 patients (40/803 KT (4.9%), 21/220 MHD (9.5%)). Prevalence of (+)COVID-19 was 3.2% in KT and 3.6% in MHD patients. Thirty-four (26 KT and 8 MHD) were (+)COVID-19 and 27 (14 KT and 13 MHD) (−)COVID-19. In comparison with (−)COVID-19 patients, (+)COVID-19 showed higher frequency of typical viral symptoms (cough, dyspnea, asthenia and myalgias), pneumonia (88.2% vs. 14.3%) and LDH and CRP while lower phosphate levels, need of hospital admission (100% vs. 63%), use of non-invasive mechanical ventilation (36% vs. 11%) and mortality (38% vs. 0%) (p < 0.001). Time from symptoms onset to admission was longer in patients who finally died than in survivors (8.5 vs. 3.8, p = 0.007). In KT and MHD patients, (+)COVID-19 shows more clinical severity than suspected non-confirmed cases. Prompt RT-PCR is mandatory to confirm COVID-19 diagnosis.

【 授权许可】

Unknown