Fabrication of highly stretchable hydrogel based on crosslinking between alendronates functionalized poly-γ-glutamate and calcium cations

Materials Today Bio

Mitsuru Akashi¹  João F. Mano²  Akihiro Nishiguchi³  Michiya Matsusaki³  Masahiko Nakamoto³  Moe Noguchi³ 

[1] Corresponding author.;Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, Campus Universitario de Santiago, 3810-193, Aveiro, Portugal;Division of Applied Chemistry, Osaka University, Graduate School of Engineering, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan;

关键词: Biodegradable polymer;    Hydrogel;    Alendronate;    Poly-γ-glutamic acid;   

DOI  :  

来源: DOAJ

【 摘 要 】

We report a highly stretchable hydrogel based on the crosslinking structure between calcium cations and alendronates (ALN) conjugated with poly-γ-glutamate (γ-PGA), a typical biodegradable polymer. γ-PGA with ALN (γ-PGA-ALN) forms the hydrogel in the aqueous solution containing CaCl2. The hydrogel shows 2000% of stretchability and reversible stretching without failure at a strain of 250%. The fracture strain and stress are tunable by varying the concentration of either γ-PGA-ALN or CaCl2, indicating the importance of fine-tuning of the density of the cross-linkage to control the mechanical properties of the hydrogel. We believe the biodegradable polymer based highly stretchable hydrogel has potential for use in various fields such as tissue engineering.

【 授权许可】

Unknown