Cell Cycle Activity of Neurogenic and Oligodendrogenic Progenitors in the Diseased Mammalian Brain

Frontiers in Neuroscience

Max eSchulze-Steikow¹  Federico eCalegari¹  Sara eBragado Alonso¹ 

[1] Center for Regenerative Therapies Dresden - DFG Research Center and Cluster of Excellence;

关键词: Cell Cycle;    Neural Stem Cells;    Neurodegenerative Diseases;    adult neurogenesis;    oligodendrocyte precursor cell (OPC);   

DOI  :  10.3389/fnins.2014.00039

来源: DOAJ

【 摘 要 】

Basic research during embryonic development has led to the identification of general principles governing cell cycle progression, proliferation and differentiation of mammalian neural stem cells (NSC). These findings were recently translated to the adult brain in an attempt to identify the overall principles governing stemness in the two contexts and allowing us to manipulate the expansion of NSC for regenerative therapies. However, and despite a huge literature on embryonic neural precursors, very little is known about cell cycle parameters of adult neural, or any other somatic, stem cell. In this review, we briefly discuss the long journey of NSC research from embryonic development to adult homeostasis, aging and therapy with a specific focus on their quiescence and cell cycle length in physiological conditions and neurological disorders. Particular attention is given to a new important player in the field, oligodendrocyte progenitors, while discussing the limitation hampering further development in this challenging area.

【 授权许可】

Unknown