Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus

International Journal of Molecular Sciences

Adriana Magalska¹  Hanna Sas-Nowosielska¹ 

[1] Laboratory of Molecular Bases of Cell Motility, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland;

关键词: lncRNA;    neuronal nucleus;    nuclear architecture;   

DOI  :  10.3390/ijms22073478

来源: DOAJ

【 摘 要 】

The ability to regulate chromatin organization is particularly important in neurons, which dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play important architectural roles in organizing different nuclear domains like inactive chromosome X, splicing speckles, paraspeckles, and Gomafu nuclear bodies. LncRNAs are abundantly expressed in the nervous system where they may play important roles in compartmentalization of the cell nucleus. In this review we will describe the architectural role of lncRNAs in the nuclei of neuronal cells.

【 授权许可】

Unknown