Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology

Frontiers in Cell and Developmental Biology

Shihai Zhang²  Fang Chen³  Wutai Guan³  Jinghui Heng⁴  Min Tian⁴  Jiaming Chen⁴  Zhihui Wu⁴ 

[1] College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China;Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, United States;Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China;Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China;

关键词: mammary epithelial cells;    AMPK;    milk fat;    milk protein;    lactose;   

DOI  :  10.3389/fcell.2020.00530

来源: DOAJ

【 摘 要 】

Activated protein kinase (AMP)-activated protein kinase (AMPK) senses the cellular energy status and coordinates catabolic and anabolic processes. Extensive studies have proposed that AMPK regulates energy homeostasis, cell growth, autophagy, mitochondrial biology and inflammation. The biological functions of AMPK vary in different tissues or organs. As a unique organ that produces milk, the mammary gland has recently attracted substantial research attention. This review discusses how AMPK in the mammary gland is activated by energy deprivation and heat stress via the activation of canonical and non-canonical pathways. In addition, the important downstream targets of AMPK and their functions in the mammary gland, especially during milk synthesis, are summarized in the review.

【 授权许可】

Unknown