Radical carbonylations using a continuous microflow system

Beilstein Journal of Organic Chemistry

Md. Taifur Rahman¹  Ilhyong Ryu¹  Naoya Kamata¹  Takahide Fukuyama¹ 

[1] Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan;

关键词: continuous flow system;    microreactor;    radical carbonylation;    radical mediator;    V-65;   

DOI  :  10.3762/bjoc.5.34

来源: DOAJ

【 摘 要 】

Radical-based carbonylation reactions of alkyl halides were conducted in a microflow reactor under pressurized carbon monoxide gas. Good to excellent yields of carbonylated products were obtained via radical formylation, carbonylative cyclization and three-component coupling reactions, using tributyltin hydride or TTMSS as a radical mediator.

【 授权许可】

Unknown