Hyperuricemia as a Risk Factor for Cardiovascular Diseases

Journal of Biomedicine and Translational Research

Nani Maharani¹  Udin Bahrudin²  Fikri Taufiq³  Masanari Kuwabara⁴  Ichiro Hisatome⁵  Peili Li⁵  Haruaki Ninomiya⁵ 

[1] Faculty of Medicine,Diponegoro University, Indonesia;Faculty of Medicine, Diponegoro University, Indonesia;Faculty of Medicine, Sultan Agung Islamic University, Indonesia;Toranomon Hospital, Japan;Tottori University, Japan;

关键词: hyperuricemia;    cardiovascular disease;    uric acid transporter;    xanthine oxidase;    inflammasome;    guideline;   

DOI  :  10.14710/jbtr.v6i3.9383

来源: DOAJ

【 摘 要 】

domain containing 3(NLRP3) inflammasome, and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1β and IL-18 secretion. Soluble UA accumulates intracellularly through UA transporters (UAT) in vascular and atrial myocytes, causing endothelial dysfunction ad atrial electrical remodeling. XOR generates reactive oxygen species (ROS) that lead to cardiovascular diseases. Since it remains unclear whether asymptomatic hyperuricemia could be a risk factor for cardiovascular and kidney diseases, European and American guidelines do not recommend pharmacological treatment for asymptomatic patients with cardio-renovascular diseases. The Japanese guideline, on the contrary, recommends pharmacological treatment for hyperuricemia with CKD to protect renal function, and it attaches importance of the cardio-renal interaction for the treatment of asymptomatic hyperuricemia patients with hypertension and heart failure.

【 授权许可】

Unknown