Coagulation markers in patients with coronary artery disease

Journal of Biological Research

YuliyaTyravska¹  LiudmylaOstapchenko²  OlexiiSavchuk²  TetianaMarynenko²  TetianaVovk²  NataliiaRaksha²  Tetiana Halenova³ 

[1] Bogomolets National Medical University, Kyiv;Taras Shevchenko National University of Kyiv, Kyiv;Taras Shevchenko National University of Kyiv;

关键词: coronary artery disease;    soluble fibrin monomer complexes;    fibrinogen;    prothrombin;    vitamin K-dependent proteins;    size exclusion chromatography;   

DOI  :  10.4081/jbr.2022.10259

来源: DOAJ

【 摘 要 】

Coronary artery disease (CAD) is a major public health problem all over the world, and although diagnostic and treatment approaches are improving, the majority of individuals who suffer CAD will not survive. Therefore, it is a clinical demand to find out new biomarkers for identification of CAD in the earlier stage. The purpose of this study was to determine whether qualitative and quantitative alterations of plasma soluble fibrin monomer complexes (SFMCs) are associated with cardiovascular events. Additionally, some other well-known biomarkers of hypercoagulation state, such as fibrinogen, and prothrombin were analyzed in plasma of patients with different coronary artery pathologies. We found that plasma SFMC concentrations were remarkably increased in all tested CAD groups. Moreover, the development of CAD was accompanied by the changes in both quantity and quality of SFMC composition compared to that of healthy subjects. Our results also demonstrated the elevated level of high molecular weight vitamin K-dependent protein (VKDP) complexes in plasma of CAD patients which could be used as a potential biomarker of hypercoagulation state. More studies are clearly needed to investigate whether SFMCs or abnormal forms of VKDPs affect cardiovascular events under CAD development and progression.

【 授权许可】

Unknown