Factor XIII B Subunit Polymorphisms and the Risk of Coronary Artery Disease

International Journal of Molecular Sciences

Zoltán A. Mezei²  Zsuzsanna Bereczky²  Éva Katona²  Réka Gindele²  Emília Balogh³  Szilvia Fiatal¹  László Balogh³  István Czuriga³  Róza ఝány¹  István 짞s³  László Muszbek² 

[1] Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary; E-Mails:;Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary; E-Mails:;Department of Cardiology, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary; E-Mails:

关键词: factor XIII (FXIII);    factor XIII B subunit (FXIII-B);    polymorphism;    coronary artery disease;    fibrinogen;    myocardial infarction;    risk assessment;   

DOI  :  10.3390/ijms16011143

来源: mdpi

【 摘 要 】

The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII) B subunit (FXIII-B) polymorphisms on the risk of coronary artery disease, and on FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classified according to the presence of significant coronary atherosclerosis (CAS) and history of myocardial infarction (MI). The F13B gene was genotyped for p.His95Arg and for intron K nt29756 C>G polymorphisms; the latter results in the replacement of 10 C-terminal amino acids by 25 novel amino acids. The p.His95Arg polymorphism did not influence the risk of CAS or MI. The FXIII-B intron K nt29756 G allele provided significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. However, this effect prevailed only in the presence of the FXIII-A Leu34 allele, and a synergism between the two polymorphisms was revealed. Carriers of the intron K nt29756 G allele had significantly lower FXIII levels, and FXIII levels in the lower tertile provided significant protection against MI. It is suggested that the protective effect of the combined polymorphisms is related to decreased FXIII levels.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.