期刊论文详细信息
International Journal of Clinical and Experimental Medicine | |
Study on the association between IL-1β, IL-8 and IL-10 gene polymorphisms and risk of coronary artery disease | |
Baojun Ren1  Qiang She1  | |
关键词: IL-1β; IL-8; IL-10; polymorphism; coronary artery disease; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
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【 摘 要 】
We aimed to evaluate the role of genetic polymorphisms in IL-1β, IL-8 and IL-10 in the risk of coronary artery disease (CAD). We identified 325 patients with CAD and 342 control subjects without CAD between January 2013 and December 2014. Genotyping of IL-1β +3954 C/T, IL-1β -511 C/T, IL-8-251T/A, IL-10-1082A/G and IL-10-819C/T was performed in a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). By Multivariate logistic regression analysis, the GG and AG+GG genotypes of IL-10-1082A/G were significantly associated with an increased risk of CAD. The ORs (95% CI) for GG and AG+GG genotypes were 2.12 (1.32-3.43) and 1.56 (1.14-2.14), respectively. Patients carrying the AG+GG genotype of IL-10-1082A/G was associated with an increased risk of CAD in those with hypertension, diabetes mellitus and smokers, and the ORs (95% CI) were 1.41 (0.93-2.14), 7.13 (2.28-23.56) and 2.12 (1.17-3.89), respectively. Our study found that IL-10-1082A/G polymorphism is associated with an increased risk of CAD, especially in hypertension, diabetes mellitus and smokers.【 授权许可】
Unknown
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RO201912140865520ZK.pdf | 425KB | ![]() |