Glucagon Control on Food Intake and Energy Balance

International Journal of Molecular Sciences

Ruben Nogueiras¹  Mar Quiñones¹  Carlos Diéguez¹  Johan Fernø²  Omar Al-Massadi³ 

[1]Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain

[2]Hormone Laboratory, Haukeland University Hospital, N-5020 Bergen, Norway

[3]Inserm UMR-S1270, Sorbonne Université, Faculté des Sciences et d’Ingénierie, Institut du Fer a Moulin, 75005 Paris, France

关键词: glucagon;    energy balance;    food intake;    body weight;    energy expenditure;    thermogenesis;    lipid metabolism;    obesity;   

DOI  :  10.3390/ijms20163905

来源: DOAJ

【 摘 要 】

Glucagon exerts pleiotropic actions on energy balance and has emerged as an attractive target for the treatment of diabetes and obesity in the last few years. Glucagon reduces body weight and adiposity by suppression of appetite and by modulation of lipid metabolism. Moreover, this hormone promotes weight loss by activation of energy expenditure and thermogenesis. In this review, we cover these metabolic actions elicited by glucagon beyond its canonical regulation of glucose metabolism. In addition, we discuss recent developments of therapeutic approaches in the treatment of obesity and diabetes by dual- and tri-agonist molecules based on combinations of glucagon with other peptides. New strategies using these unimolecular polyagonists targeting the glucagon receptor (GCGR), have become successful approaches to evaluate the multifaceted nature of glucagon signaling in energy balance and metabolic syndrome.

【 授权许可】

Unknown