Photothermal hydrogel platform for prevention of post-surgical tumor recurrence and improving breast reconstruction

Journal of Nanobiotechnology

Xi Yang¹  Yuanfeng Wei¹  Cheng Yi¹  Ling Gao¹  Yongzhi Wu²  Bowen Tan²  Jinfeng Liao² 

[1] Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University;State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University;

关键词: Breast cancer;    Hydrogel;    Microspheres;    Photothermal therapy;    Breast reconstruction;   

DOI  :  10.1186/s12951-021-01041-w

来源: DOAJ

【 摘 要 】

Abstract Background As one of the leading threats for health among women worldwide, breast cancer has high morbidity and mortality. Surgical resection is the major clinical intervention for primary breast tumor, nevertheless high local recurrence risk and breast tissue defect remain two main clinical dilemmas, seriously affecting survival and quality of life of patients. Experimental We developed a thermoresponsive and injectable hybrid hydrogel platform (IR820/Mgel) by integration of co-loaded porous microspheres (MPs) and IR820 for preventing postoperative recurrence of breast cancer via photothermal therapy and promoting subsequent breast reconstruction. Results Our results suggested that IR820/Mgel could quickly heated to more than 50.0 ℃ under NIR irradiation, enabling killing effect on 4T1 cells in vitro and prevention effect on post-surgical tumor recurrence in vivo. In addition, the hydrogel platform was promising for its minimal invasion and capability of filling irregularly shaped defects after surgery, and the encapsulated MPs could help to increase the strength of gel to realize a long-term in situ function in vivo, and promoted the attachment and anchorage property of normal breast cells and adipose stem cells. Conclusions This photothermal hydrogel platform provides a practice paradigm for preventing locally recurrence of breast cancer and a potential option for reconstruction of breast defects. Graphic abstract

【 授权许可】

Unknown