Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications

International Journal of Molecular Sciences

Wei Hu¹  Xiang Song¹  Yong Zhao¹  Haibo Yu¹  Jingyu Sun² 

[1] Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA;Department of Chemistry and Chemistry Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA;

关键词: extracellular vesicle;    exosomes;    isolation;    cell-to-cell communication;    biomarker;    diabetes;   

DOI  :  10.3390/ijms21145163

来源: DOAJ

【 摘 要 】

Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-to-micrometer vesicles released from nearly all cellular types. EVs comprise a mixture of bioactive molecules (e.g., mRNAs, miRNAs, lipids, and proteins) that can be transported to the targeted cells/tissues via the blood or lymph circulation. Recently, EVs have received increased attention, owing to their emerging roles in cell-to-cell communication, or as biomarkers with the therapeutic potential to replace cell-based therapy. Diabetes comprises a group of metabolic disorders characterized by hyperglycemia that cause the development of life-threatening complications. The impacts of conventional clinical treatment are generally limited and are followed by many side effects, including hypoglycemia, obesity, and damage to the liver and kidney. Recently, several studies have shown that EVs released by stem cells and immune cells can regulate gene expression in the recipient cells, thus providing a strategy to treat diabetes and its complications. In this review, we summarize the results from currently available studies, demonstrating the therapeutic potentials of EVs in diabetes and diabetic complications. Additionally, we highlight recommendations for future research.

【 授权许可】

Unknown